Yuichiro Hori

「Yuichiro Hori」
Degree
Ph.D.
Position, Research site
Associate Professor, Osaka University Graduate School of Engineering
URL
http://www-molpro.mls.eng.osaka-u.ac.jp/English/indexeng/indexENG.html
Research Field
Chemical biology, Fluorescence imaging, Protein chemistry, Peptide engineering

Original Papers

  1. Yuko Kamikawa, Yuichiro Hori, Kazuo Yamashita, Lin Jin, Shinya Hirayama, Daron M. Standley, Kazuya Kikuchi. Design of a protein tag and fluorogenic probe with modular structure for live-cell imaging of intracellular proteins. Chem. Sci. Vol.7, No.1. 308-314 (2016)
  2. Hori Y, Hirayama S, Sato M, Kikuchi K..:Redesign of a Fluorogenic Labeling System To Improve Surface Charge, Brightness, and Binding Kinetics for Imaging the Functional Localization of Bromodomains. Angew Chem Int Ed Engl. 2015 Oct 5. doi: 10.1002/anie.201506935. [Epub ahead of print]
  3. Baba R, Hori Y, Kikuchi K. Intramolecular Long-Distance Nucleophilic Reactions as a Rapid Fluorogenic Switch Applicable to the Detection of Enzymatic Activity. Chemistry. 2015 Feb 6.
  4. Mizukami S, Hori Y, Kikuchi K. Small-molecule-based protein-labeling technology in live cell studies: probe-design concepts and applications. Acc Chem Res. 2014 Jan 21;47(1):247-56.
  5. Yuichiro Hori, Tomoya Norinobu, Motoki Sato, Kyohei Arita, Masahiro Shirakawa, Kazuya Kikuchi.:Development of Fluorogenic Probes for Quick No-Wash Live-Cell Imaging of Intracellular Proteins. Jouranl of the American Chemical Society, Vol.135, No.33 12360-12365 (2013)(Selected as a JACS spotlighhts Article)
  6. Hori, Y., Nakaki, K., Sato, M., Mizukami, S., Kikuchi, K. Development of Protein-Labeling Probes with Redesigned Fluorogenic Switch Based on Intramolecular Association for No-wash Live-cell Imaging. Angew. Chem. Int. Ed. 51, 5611-5614 (2012)
  7. Baba, R., Hori, Y., Mizukami, S. Kikuchi, K. Development of Fluorogenic Probe with Transesterification switch for Detection of Histone Deacetylase Activity. J. Am. Chem. Soc. 134, 14310-14313 (2012)
  8. Dhara, K., Hori, Y., Baba, R., Kikuchi, K. Fluorescent Probe for Detection of Histone Deacetylase Activity Based on Aggregation-Induced Emission. Chem. Commun. 48, 11534-11536 (2012)
  9. Watanabe, S., Mizukami, S., Akimoto, Y., Hori, Y., Kikuchi, K. Intracellular protein labeling with prodrug-like probes using a mutant β-lactamase tag. Chem. Eur. J. 17, 8342-8349 (2011)
  10. Yoshimura, A., Mizukami, S., Hori, Y., Watanabe, S., Kikuchi, K. Chembiochem 12, 1031-1034 (2011)
  11. Mizukami, S., Hosoda, M., Satake, T., Okada, S., Hori, Y., Furuta, T., Kikuchi, K. Photocontrolled Compound Release System Using Caged Antimicrobial Peptide, J. Am. Chem. Soc. 132, 9524-9525 (2010)
  12. Watanabe, S., Mizukami, S., Hori, Y., Kikuchi, K. Multicolor Protein Labeling in Living Cells Using Mutant β-Lactamase-Tag Technology. Bioconjug. Chem. 21, 2320-2326, (2010)
  13. Hori, Y., Egashira, Y., Kamiura, R., Kikuchi, K. Noncovalent-interaction-promoted ligation for protein labeling. Chembiochem 11, 646-648 (2010)
  14. Hori, Y., Ueno, H., Mizukami, S., Kikuchi, K. Photoactive Yellow Protein-Based Protein Labeling System with Turn-on Fluorescence Intensity. J. Am. Chem. Soc. 131, 16610-16611(2009)
  15. Mizukami, S., Watanabe, S., Hori, Y., Kikuchi, K. Covalent protein labeling based on noncatalytic beta-lactamase and a designed FRET substrate. J. Am. Chem. Soc. 131, 5016-5017 (2009)
  16. Mizukami, S., Takikawa, R., Sugihara, F., Hori, Y., Tochio, H., Walchli, M., Shirakawa, M., Kikuchi, K. Paramagnetic relaxation-based 19F MRI probe to detect protease activity. J. Am. Chem. Soc. 130, 794-795 (2008)
  17. Vila-Perelló, M., Hori, Y., Ribó, M., Muir, T. W. Activation of protein splicing by protease- or light-triggered O to N acyl migration. Angew. Chem. Int. Ed. 47, 7764-7767 (2008)
  18. Hori, Y., Sugiura, Y. Effects of Zn(II) Binding and Apoprotein Structural Stability on the Conformation Change of Designed Antennafinger Proteins. Biochemistry 43, 3068-3074, (2004)
  19. Hori, Y., Sugiura, Y. Conversion of Antennapedia Homeodomain to Zinc Finger-like Domain: Zn(II)-Induced Change in Protein Conformation and DNA Binding. J. Am. Chem. Soc. 124, 9362-9363 (2002)
  20. Nagaoka, M., Kaji, T., Imanishi, M., Hori, Y., Nomura, W., Sugiura, Y. Multi-Connection of Identical Zinc Finger: Implication for DNA Binding Affinity and Unit Modulation of Three Zinc Finger Domain. Biochemistry 40, 2932-2941 (2001)
  21. Hori, Y., Suzuki, K., Okuno, Y., Nagaoka, M., Futaki, S., Sugiura, Y. Artificial Zinc Finger Peptide Containing a Novel His4 Domain. J. Am. Chem. Soc. 122, 7648-7653 (2000)
  22. Imanishi, M., Hori, Y., Nagaoka, M., Sugiura, Y. DNA-Bending Finger: Artificial Design of 6-Zinc Finger Peptides with Polyglycine Linker and Induction of DNA Bending. Biochemistry 39, 4383-4390 (2000)
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Reviews

  1. Yuichiro Hori, Kazuya Kikuchi Protein Labeling with Fluorogenic Probes for No-Wash Live-Cell Imaging of Proteins Current Opinion in Chemical Biology, Vol. 17, No. 4, 644-650 (2013)
  2. Yuichiro Hori, Reisuke Baba, Kazuya Kikuch. Development of Fluorogenic Probes for the Detection of Histone Deacetylase Activity. YAKUGAKU ZASSHI Vol. 135(2015) No. 1, p.23-29.
  3. 堀 雄一郎、菊地 和也「ヒストン脱アセチル化酵素の活性を検出する化学プローブの開発」 生体の科学 2014.12.15.
  4. 堀 雄一郎、菊地 和也「タンパク質イメージング技術の新展開」 バイオサイエンスとインダストリー「目で見るバイオ」2014年 VOL.72 NO.3.
  5. 堀 雄一郎、菊地 和也「PYPタグと発蛍光プローブを用いた生細胞タンパク質イメージング法の開発と応用」 バイオサイエンスとインダストリー、「トピックス」2014年 VOL.72 NO.3.
  6. 堀　雄一郎、菊地　和也 「発蛍光型スイッチ機能をもったタンパク質ラベル化技術の開発による細胞内標的分子イメージング」, CSJカレントレビュー, Vol 12 (2013)
  7. 堀　雄一郎、菊地　和也 「PYPタグと発蛍光プローブを利用したタンパク質の生細胞蛍光イメージング」, 化学と生物, in press (2013)
  8. 堀　雄一郎、菊地　和也 「次世代型タンパク質蛍光標識技術　−化学アプローチに基づくタンパク質蛍光イメージング」,　化学, 67, 68-69 (2012)
  9. Sadhu, K. K., Mizukami, S., Hori, Y., Kikuchi, K. Switching modulation for protein labeling with activatable fluorescent probes. Chembiochem 12, 1299-1308 (2011)
  10. Yuichiro Hori，菊地 和也 「合成蛍光プローブと発現タンパク質を用いた新規タンパク質ラベル化システム」, 生化学, 83, 135-139 (2011)
  11. Yuichiro Hori 「蛍光蛋白質の夜明け：GFP の構造解明」蛋白質 核酸 酵素「ケミカルバイオロジー」, 52, 1768-1769 (2007)
  12. Imanishi, M., Hori, Y., Nagaoka, M., Sugiura, Y. Design of Novel Zinc Finger Proteins: Toward Artificial Control of Specific Gene Expression. Eur. J. Pharm. Sci. 13, 91-97 (2001)
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