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JST Press Release

May 8, 2014
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666
URL http://www.jst.go.jp/EN/index.html

Epigenetic regulator Uhrf1 ensures symbiotic relationship between gut microbes and the immune systems

Mammals and gut microbiota have co-evolved over 100 million years to establish a unique ecosystem based on symbiotic interactions. Colonization by gut microbiota facilitates expansion of colonic Foxp3+ regulatory T (Treg) cells, which play a pivotal role in containment of excessive inflammation. The molecular machinery controlling Treg homeostasis in the gut, however, remains largely unknown. Here we report that a DNA methylation adaptor Uhrf1 regulates homeostasis and functionality of colonic Treg cells. This mechanism secures symbiotic host-microbe interactions without an inflammatory response.

Researcher Information

Research Area: “Epigenetic control and biological functions”
Research Theme:“Epiegenetic modifications of the gut immune system by commensal microbiota”

Journal Information

Yuuki Obata, Yukihiro Furusawa, Takaho A Endo, Jafar Sharif, Daisuke Takahashi, Koji Atarashi, Manabu Nakayama, Satoshi Onawa, Yumiko Fujimura, Masumi Takahashi, Tomokatsu Ikawa, Takeshi Otsubo, Yuki I Kawamura, Taeko Dohi, Shoji Tajima, Hiroshi Masumoto, Osamu Ohara, Kenya Honda, Shohei Hori, Hiroshi Ohno, Haruhiko Koseki and Koji Hase. “The epigenetic regulator Uhrf1 facilitates proliferation and maturation of colonic regulatory T cells”
Nature Immunology, Published online 28 April 2014
doi: 10.1038/ni.2886


[About Research]
Koji Hase, Ph.D.
Professor, Department of Biochemistry, Faculty of Pharmacy, Keio University
URL: http://www.ims.u-tokyo.ac.jp/dmb/index-e.html

[About Program]
Koji Matsuo, Takafumi Kawaguchi, and Yuichi Mine
Life Innovation Group, Department of Innovation Research, JST


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/