Summary of the project

This project aims to scientifically explore how the mind emerges and changes by studying the brain in action. To do this, we use specially prepared mice whose brain activity can be directly observed and even artificially altered in real time.
We are developing a virtual reality (VR) system where mice receive various sensory inputs while moving around freely. In addition, we create a shared VR space—like a "mouse metaverse"—where two mice can interact socially. By tracking their brain activity during these social exchanges, we can begin to understand their internal mental states.
We also use a cutting-edge technique called optogenetics, which allows us to control specific parts of the brain using light. By intentionally altering brain activity, we can see how these changes affect the mice’s behaviors and mental states.
Through these approaches, we hope to uncover the biological foundations of the mind. Ultimately, this research could provide new insights into human mental health and lead to better ways to understand and treat mental and neurological conditions.

Milestone by the end of project (year 2024)

1. A VR system that visualizes changes in the mouse’s mental state

We will complete a VR-based setup where mice engage in social interactions, and we will record their brain activity in real time. This system will help identify patterns in the brain that correspond to emotions such as curiosity and friendliness (positive states) or fear and avoidance (negative states).

2. A system for controlling brain activity with light

We will develop a method to stimulate specific brain areas by shining light through the mouse’s skull. By doing so, we can alter brain network activity and observe how the mouse’s behavior changes. This will help us understand how brain function relates to shifts in mental state.

R&D theme progress reports

• [1] Establishment of a VR system to visualize brain function network dynamics
• [2] Optical manipulation of functional brain networks by optogenetics
• Progress Report (580KB)

Leader's institution

Kobe University

R&D institutions

Kobe University

PDF Download

• Summary of the project (598KB)