R&D Project
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Goal 2 R&D Projects (Selected in 2020)Comprehensive Mathematical Understanding of the Complex Control System between Organs and Challenge for Ultra-Early Precision MedicineJPMJMS2021
Project manager (PM)AIHARA KazuyukiUniversity Professor / Professor Emeritus, Office of University Professor, The University of Tokyo
Summary of the project
We will establish integrated research between mathematical studies with mathematical data analysis & modeling analysis, and experimental & clinical studies on physiological interaction and control between organs. In particular, we develop DNB (Dynamical Network Biomarkers) theory and its complementary theory such as energy landscape analysis & AI like spatiotemporal information transforming learning to detect the pre-disease states (Mebyo) and gradual deviation from healthy states at ultra-early timing before tipping points to disease states and propose methodology for Ultra-Early Medicine based on such ultra-early detection as well as treatments with control theory on physiological networks. The long-term purpose of this project is to realize a society equipped with ultra-early disease prediction and intervention systems by 2050. We are also developing the comprehensive Mebyo database and an ELSI supporting system for ultra-early medicine. Further, we are collaborating with other projects of Goal2 as well as projects of other Moonshot Goals through our mathematical methodology composed of mathematical data & modeling analysis.
Milestone by year 2030
Based on advanced mathematical & AI studies, we will develop mathematical & AI methodology supporting ultra-early precision medicine by a predictive and preventive system to detect early warning signals of diseases in the pre-disease states before diseases will really occur and to treat imminent diseases before the disease onset by network control theory.
R&D Items through FY2025
- [1] Mathematical Approach to Complex Control System between Organs
- [2] Experimental Approach to Complex Control System between Organs
- [3] Mathematical Collaboration with Other Moonshot Projects, Development of Data Base, and ELSI Supporting System
- Progress Report (668KB)
R&D Items from FY2026
- [101] Integration of Mathematics and Biomedical Engineering in the Detection of Preclinical Hematopoietic Tumors
- [102] Integration of Mathematical and Biomedical Engineering for Ultra-Early Detection of Myocardial Infarction
- [111] Mathematical Approach to Complex Control System between Organs
- [112] Medical Approach to Complex Control System between Organs
- [113] Cross-cutting Collaborative Research
Performers
| R&D Item [101] | KOIZUMI Keiichi | University of Toyama |
|---|---|---|
| R&D Item [102][112] | FUJIU Katsuhito | Institute of Science Tokyo |
| R&D Item [111] | AIHARA Kazuyuki | The University of Tokyo |
| R&D Item [111] | SUZUKI Hideyuki | The University of Osaka |
| R&D Item [111] | MASUDA Naoki | University of Michigan |
| R&D Item [111] | IMURA Jun-ichi | Institute of Science Tokyo |
| R&D Item [111] | KAJI Shizuo | Kyoto University |
| R&D Item [111] | TAKEUCHI Tomoya | Chiba Institute of Technology |
| R&D Item [111] | IWAMI Shingo | Nagoya University |
| R&D Item [111] | TANAKA Gouhei | Nagoya Institute of Technology |
| R&D Item [111] | SVIRIDOVA Nina | Tokyo City University |
| R&D Item [111] | TAMADA Yoshinori | Hirosaki University |
| R&D Item [111] | AWAZU Akinori | Hiroshima University |
| R&D Item [111] | MORINO Kai | Kyushu University |
| R&D Item [111] | OKAMOTO Yuji | RIKEN |
| R&D Item [111] | MATSUBARA Yasuko | The University of Osaka |
| R&D Item [112] | SAITO Shigeru | University of Toyama |
| R&D Item [112] | HAYASHI Shusaku | Kyoto Pharmaceutical University |
| R&D Item [112] | KIMURA Takahiro | The Jikei University School of Medicine |
| R&D Item [112] | WATANABE Takamitsu | The University of Tokyo |
| R&D Item [112] | HOSHINO Ayuko | The University of Tokyo |
| R&D Item [113] | FUJIWARA Kantaro | The University of Tokyo |
| R&D Item [113] | IIDA Keita | The University of Osaka |
| R&D Item [113] | NOSHITA Koji | Kyushu University |
| R&D Item [113] | YAMAJI Kazutsuna | National Institute of Informatics |
| R&D Item [113] | IIJIMA Yoshihiko | Fujita Health University |
| R&D Item [113] | ISOBE Tetsu | Keio University |
| R&D Item [113] | YOSHIDA Masayuki | Institute of Science Tokyo |
| R&D Item [113] | KAMISATO Ayako | National Center for Child Health and Development |
| R&D Item [113] | FUJITA Takanori | Co-Innovation University |
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- Summary of the project (361 KB)