Functional analysis of membrane lipid metabolism and microdomains in cancer invasion and metastasis
Invadopodia are ventral membrane protrusions formed by invasive cancer cells cultured on physiological substrates. Invadopodia have a matrix degradation activity and are therefore implicated in cancer invasion and metastasis. However, the roles of invadopodia in vivo and the molecular mechanisms that regulate invadopodium formation remain to be determined. The aim of this study is to reveal functions of membrane lipid metabolism and microdomains in invadopodium formation. This study would lead to the identification of novel therapeutic targets for cancer metastasis.
