Highly functional catalysts based on acid-base combined supramolecular and dynamic complexation

Research Project Outline

It is one of the most important subjects on synthetic organic chemistry to develop practical chemozymes bearing enzymatic functions such as remote asymmetric induction, stereocontrol of cascade reactions, a high level of molecular recognition, etc. which are hard to be controlled by unimolecule catalysts. We develop highly functional chemoenzymes which are superior to natural enzymes and establish to their efficient preparation methods towards an environmentally benign and precision organic synthetic technology. The key to introduce a versatile functionality into chemoenzymes is to design supramolecular dynamic salt catalysts based on acid-base combination chemistry.