Unraveling How Cells Connect Global Tissue Asymmetry to Individual Cell Polarity

Research Project Outline

Our body and organs take asymmetrical shape along various axes and this global asymmetry is coupled to polarity of individual cells in epithelial planes (planar cell polarity). We are exploring logic of this connection. Our approaches include tracking key molecules and subcellular structures in live animals and mathematical analysis of those behaviors. Planar cell polarity underlies critical epithelial functions and our longterm goal is to contribute to understanding basis of diseases that are caused by defective cell polarization.

Research Director
Professor, Kyoto University
Research Started
Research Area
The Dynamic Mechanism of and Fundamental Technology for Biological System
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