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Mechanism of Ultradian Rhythms of Gene Expression

Research Project Outline

During cell proliferation and differentiation, many genes function in proper timings, but biological clocks that regulate these timings remain to be analyzed. We have been elucidating that the transcription factors Hes1 and Hes7 function as ultradian clocks and that there are other ultradian oscillators, but their whole picture is not known.In this research project, we will make and evaluate mathematical models and elucidate the mechanism of ultradian oscillators and their roles in cellular events.

Research Director
RyoichiroKageyama
Affiliation
Director, Kyoto University
Research Started
2006
Status
ongoing
Research Area
The Dynamic Mechanism of and Fundamental Technology for Biological System
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