Establishment of the Analytical Basis toward Comprehensive Understanding of the Ubiquitin System

Research Project Outline

The ubiquitin system controls a number of important biological phenomena, and more than a thousand of enzymes are involved in the system. However, the relationship between the enzymes and their corresponding substrates has not yet been well established, and the development of technology that comprehensively analyzes the ubiquitin system is necessary. In this project, we intend to develop a new methodology by the combination of genetics and proteomics to understand the ubiquitylation as a system, by which molecular mechanisms underlying a number of biological phenomena will be elucidated.

Related Links

• Laboratory Website: http://www.bioreg.kyushu-u.ac.jp/saibou/index.html (Japanese)