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Control of allergic diseases by regulation of human mast cell activation

Research Project Outline

Allergy is induced by the release of chemical mediators from mast cells. We identified novel immunoreceptors, Allergin-1 and MAIR-I, which inhibit the release of chemical mediators from mast cells. In this project, we will search novel inhibitory immunoreceptors expressed on human mast cells and clarify their role in the regulatory mechanism of allergic diseases. Furthermore, we will develop novel therapeutic approach targetting the inhibitory immunoreceptors on mast cells for allergic diseases.

Research Director
AkiraShibuya
Affiliation
Professor, University of Tsukuba
Research Started
2010
Status
ongoing
Research Area
Etiological Basics of and Techniques for Treatment of Allergic and Autoimmune Diseases
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