Novel mechanisms of allergy and its regulation

Research Project Outline

Allergic disorders have increased in prevalence these days in industrialized countries including Japan, and become an object of public concern. We have recently discovered novel players in the pathogenesis of allergy through studies on basophils and hyper-IgE syndrome. Based on these new findings, in this project we will clarify novel mechanisms of allergy and its regulation at the molecular, cellular and in vivo levels, and explore key strategies toward the development of new therapies for allergic disorders.