Regulation of immune response and infection by targeting paired receptors.

Research Project Outline

Paired receptors that consit of activating and inhibitory receptors play an important role in the regulation of autoimmunity. Paired receptors are also involved in host defense against various infectious diseases. In the present sutdy, we investigate recognition mechanism of a series of paired receptors as well as their functions in immune diseases and infectious diseases. Furthermore, we will develop a novel method to regulate autoimmunity and allergy as well as immunity to pathogens and tumors by modulating the function of paired receptors.