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Reprograming of Immune System by Modulation of Intracellular Signal Transduction

Research Project Outline

Helper T cell is known as a commander of immunity. After activation by antigenic stimulation, naïve helper T cells dif-ferentiate into either effector T cells responsible for positive immune reactions or regulatory T cells necessary for the negative regulation of immunity. Dysregulation of the balance between effector and regulatory T cells causes immunological disorders such as allergy and autoimmune diseases. We have discovered SOCS family proteins, which play pivotal roles in keeping such balance. In this project, we will further elucidate molecular mechanisms for the maintenance and regulation of helper T cell differentiation. Furthermore, we will develop new methods for reprogramming helper as well as memory T cells: conversion of effector and memory T cells into regulatory T cells, which will be a novel strategy for the regulation of im-munological diseases.

Research Director
Professor, Keio University School of Medicine
Research Started
Research Area
Etiological Basics of and Techniques for Treatment of Allergic and Autoimmune Diseases
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