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Mechanis of Organ Specifi c Infl ammatory/autoimmune Diseases and the Development of Its Control Approach

Research Project Outline

We recently showed dysregulation of an IL-17?triggered positive feedback loop of IL-6 signaling, which involves the activation of NF-kB and STAT3 in fi broblasts, plays a role for arthritis development in mutant mice. Because this mechanism appears to enhance experimental autoimmune encephalomy-elitis in wild-type mice, it might be a general etiologic process underlying other Th17 cell-mediated autoimmune diseases as well as chronic infl ammatory diseases. In this project, our research is focused on analyzing in vivo homeostasis of the IL-6 loop on the molecular level to identify several molecular targets to effi ciently control the enhancing level of the loop in vivo.

Research Director
Professor, Osaka University
Research Started
Research Area
Etiological Basics of and Techniques for Treatment of Allergic and Autoimmune Diseases
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Research Areas Completed
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