Research Project Outline
We will establish novel therapeutic strategies against allergic and autoimmune diseases by enhancing immunoregulatory poteintials of cell-surface receptors, such as FcgRIIB and LILRB, critical inhibitory receptors for IgG and MHC class I molecules, respectively. We plan polishing-up of intravenous g-globulin therapies and enhancement of self-tolerance by developing agonistic ligands to the critical immuno-regulatory receptors. Moreover, we will examine these basic and pre-clinic ideas in NOG mice with the humanized immune system, and will maturate our original concept into the development of versatile immunoregulatory tools for the immune system in humans.