Directed induction of chondrogenic stem / progenitor cells from dermal fibroblast culture by defined factors

Research Project Outline

The generation of iPS cells has enabled full reprogramming of somatic cells into pluripotent stem cells, followed by differentiation to other cell types of diseased organs. Alternatively, we aim to induce chondrogenic stem / progenitor cells directly from mouse dermal fibroblast culture by employing methods of directed reprogramming. Induced cells could produce homogenous cartilage tissue in vivo, providing materials with joint diseases in regenerative medicine. This approach induces cells without reversion to a pluripotent stem cell state, possibly reducing a risk of tumorigenesity and producing homogenous tissues of diseased organs.

Research Director
Associate Professor, Osaka University
Research Started
Research Area
Fundamental Technologies for Medicine Concerning the Generation and Regulation of Induced Pluripotent Stem (iPS) Cells
Research Areas by Category
Research Areas Completed
Researcher Index