In vivo directed reprogramming of neural crest cells

Research Project Outline

The iPS technology has opened a way to reprogram differentiated cells into other cell types. Progress of iPS research has mostly been made in vitro system, which requires a long-term cell culture and subsequent cell transplantation into host animals. We aim to establish an in vivo directed reprogramming technology with neural crest cells as a model. Neural crest cells are a population of stem cells that give rise to peripheral nervous system and pigment cells. The principle of technology developed for neural crest cells can also be applied to other cells/tissues, and it will therefore serve as a general basis for advanced regenerative medicine.