Analysis of molecular mechanisms involved in physiological cell reprogramming

Research Project Outline

It has emerged that somatic cell reprogramming occurs in vivo physiologically and endogenously. We have recently found the possibility that the hematopoietic stem cell (HSC) population induces reprogramming of somatic cells into the stem cell lineage through delivery of stemness factors. This reprogramming method may be utilized for regenerating damaged tissue under physiological conditions. We will attempt to define this physiological pathway of cell reprogramming at the molecular level and believe that this will contribute to the development of new technology for tissue regeneration.