A comprehensive analysis of the mechanism underlying the genome-wide epigenetic reprogramming in the germ cell lineage and its application

Research Project Outline

Germ cell development involves genome-wide epigenetic reprogramming, which occurs in a highly ordered fashion. Unveiling the mechanisms involved in this process would be important for understanding the molecular logic for epigenetic reprogramming in general, which will shed a new insight into the mechanisms underlying iPS cell induction. In this project, we aim to reveal the nature of genome-wide epigenetic reprogramming associated with early germ cell development at a high resolution, to clarify the molecular mechanisms inducing this event, and to reconstitute this event in vitro. These studies will serve as an important basis for the development of regenerative medicine.