Research Project Outline
The tissue stem cells such as mesenchymal and hematopoietic stem cells and renal progenitors are invaluable to the medical therapies for intractable diseases. This study aims 1) Establishment of induction method from iPS cell into tissue stem cell through identifying the intermediates during iPS cell differentiation, and 2) Elucidation of molecular mechanism of stem cell development using iPS cells. Our results are expected to contribute to the generation of the new basis that can not only help promote the conventional treatment with tissue stem cells but also facilitate the development of novel therapies using tissue and induced-pluripotent stem cells.