Development of personalized preventive medicine toward neurodegenerative diseases based on pathomechanistic insight explored by iPS cell technology

Research Project Outline

Recapitulation of disease-niche, by using neural cells from disease-specific iPS cells of Alzhemimer's disease or Amyotrophic lateral sclerosis, will make it possible to monitor misfolded protein, and to evaluate the responsible molecule(s) for neurodegeneration by genetic analysis or by animal experiments. The research will develop the concept, "early diagnosis and treatment", which is critical for conquering neurodegenerative diseases, into personalized preventive medicine.