Research Project Outline
Generating iPS cells from patient’s somatic cell will become one of the most important techniques for future regenerative medicine. To overcome several issues of a current method of iPS generation, which utilizes viral vectors for transgene de-livery, we will attempt to develop a new method using next-generation human artifi cial chromosomes (HACs). Further, we will extend our research based on novel insights into the in-terplay between reprogramming factors and their nuclear import/export receptors. By regulating the environment of nucleo-cytoplasmic molecular transport, we will try to further increase the effi ciency of cellular reprogramming.