Research Project Outline
Towards clinical application of human iPS cells, one of es-sential prerequisites is to gauge levels of the effi cacy and security during its therapeutic use.To this end, we fi rst estab-lish therapeutic models by using haematopietic lineage cells derived from human iPS cells in totally immuno-compromisedmice. We then reveal gene expression and epigenetic profi les of various human iPS cells genome-widely. By combining these data, we try to squeeze molecular markers thatrepresent pluripotency and tumorigenicity of human iPS cells.