Isolation of Molecular Markers that Represent Pluripotency and Tumorigenicity of Human iPS Cells

Research Project Outline

Towards clinical application of human iPS cells, one of es-sential prerequisites is to gauge levels of the effi cacy and security during its therapeutic use.To this end, we fi rst estab-lish therapeutic models by using haematopietic lineage cells derived from human iPS cells in totally immuno-compromisedmice. We then reveal gene expression and epigenetic profi les of various human iPS cells genome-widely. By combining these data, we try to squeeze molecular markers thatrepresent pluripotency and tumorigenicity of human iPS cells.

Research Director
Group Director, RIKEN
Research Started
Research Area
Fundamental Technologies for Medicine Concerning the Generation and Regulation of Induced Pluripotent Stem (iPS) Cells
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Research Areas Completed
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