Research Project Outline
iPS cells have many advantageous characteristics compared to ES cells such as avoidance of ethic issue and immune-rejection problem. However, iPS cells have apparently one major drawback about the safety issue compared to ES cells for the potential source of regenerating medicine. In our labo-ratory, we will perform experiments to lower the risk of iPS cells including trial for generating iPS cells with integration-defective lentivirus. We will also try to elucidate the molecular bases of iPS cell generation in order to obtain clues to elevate safety level of the cells.