About Project

 Bone has been traditionally regarded as a part of the skeletal and locomotor system, but recent studies suggest that bone regulates systemic biological functions such as the immune reaction in response to environmental stress. In this project, an effort will be made to reveal the molecular mechanisms underlying the interaction of the bone with other biological systems, including the immune system, and uncover the regulatory network governed by the bone, named Osteonetwork, which elucidation may impact fundamental understanding in vertebrate biology. The findings of this project will help creating the novel framework for biological understanding as well as providing a molecular basis for future pharmacological intervention into a variety of human diseases.