SUZUKI RNA Modification Project

This project aims to unveil physiological roles of RNA modifications associated with fundamental biological processes. We search for novel RNA modifications from human cells and other organisms, and determine their chemical structures by RNA mass spectrometry. We are also developing nanopore sequencing of RNA modifications assisted by neural networks and deep learning. In this project, we identify novel RNA-modifying enzymes and their genes, and study biogenesis and physiological function of the RNA modifications by generating knockout mice. We aim to elucidate molecular pathogenesis of “RNA modopathies”, human diseases caused by abnormal RNA modification. Furthermore, we attempt to control cellular processes by artificially manipulating RNA modifications, thereby establishing a technological basis for future drug discovery and therapeutic measures.



Project Title
SUZUKI RNA Modification Project
Research Area
On-going
Projects
Life Innovation
Research Term
Oct 2020 - Mar 2026 
Research
Director
Tsutomu Suzuki ( Professor, Graduate School of Engineering, The University of Tokyo)
Research
Groups
Biochemistry Group Leader:
Tsutomu Suzuki ( Professor, Graduate School of Engineering, The University of Tokyo)

Physiology Group Leader:
Fanyan Wei (Professor, Department of Modomics Biology & Medicine IDAC, Tohoku University)

Bioinformatics Group Leader:
Hiroki Ueda (Project Lecturer, Biological Data Science , Research Center for Advanced Science and Technology, The University of Tokyo)

Single-Molecule Sensing Group Leader:
Hirohito Yamazaki (Postdoctoral fellow, Department of Biological Sciences, Graduate Shool of Science, The University of Tokyo)

Research Groups

Biochemistry Group
Physiology Group
Bioinformatics Group
Single-Molecule Analysis Group

Project Headquarters

Department of Chemistry and Biotechnology,
Graduate School of Engineering,
the University of Tokyo,
7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

Project Members

  • Biochemistry Group 

    Tsutomu Suzuki

    Research Director/Biochemistry Group Leader

    Professor, Graduate School of Engineering, The University of Tokyo

    Biochemistry Group Researcher 8
    Research Assistant 19
  • Physiology Group

    Fanyan Wei

    Physiology Group Leader

    Professor, Dept. Modomics Biology & Medicine IDAC, Tohoku University

    Physiology Group Researcher 3
  • Bioinformatics Group

    Hiroki Ueda

    Bioinformatics Group Leader

    Project Lecturer, Research Center for Advanced Science and Technology, The University of Tokyo

    Bioinformatics Group Researcher 1
    Research Assistant 2
  • Single-Molecule Sensing Group

    Hirohito Yamazaki

    Single-Molecule Sensing Group Leader

    Postdoctoral fellow, Department of Biological Sciences, Graduate Shool of Science, The University of Tokyo

    Single-Molecule Sensing Group Technisian 1
    Research Assistant 2
  • Project Headquarters

    Kaori Iiyama

    Administrative Manager

    Project Specialist, School of Engineering, the University of Tokyo

Publication

Contact

Mail:info-rna<AT>chembio.t.u-tokyo.ac.jp  *Change <AT> to @