Last Update:2013.02.01

SAITOU Totipotent Epigenome > Publications




Hayashi, K., and Saitou, M. (2013).
Stepwise differentiation from naive state pluripotent stem cells to functional primordial germ cells through an epiblast-like state.
Methods in Molecular Biology, in press
Yamaji, M., Ueda, J., Hayashi, K., Ohta, H., Yabuta, Y., Kurimoto, K., Nakato, R., Shirahige, K., and Saitou, M. (2013).
PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.
Cell Stem Cell, vol12, 368-382 [Cell Stem Cell]
Kagiwada, S., Kurimoto, K., Hirota, T., Yamaji, M., and Saitou, M. (2013).
Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice.
The EMBO Journal (2013), 32, 340 - 353 [The EMBO Journal]


Hayashi, K., Ogushi, S., Kurimoto, K., Shimamoto, S., Ohta, H., and Saitou, M. (2012).
Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice.
Science, 338, 971-975. [Science]
Mochizuki, K., Tachibana, M., Saitou, M., Tokitake, Y., and Matsui, Y. (2012).
Implication of DNA demethylation and bivalent histone modification for selective gene regulation in mouse primordial germ cells.
PloS ONE, 7, e46036. [PloS ONE]
Saitou, M.., and Yamaji, Masashi. (2012).
Primordial germ cells in mice.
CSH Perspectives in Biology, 4. [CSH]
Saitou, M., Kagiwada, S., and Kurimoto, K. (2012).
Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells.
Development, 139, 15-31. [Development]


Ichiyanagi, K., Li, Y., Watanabe, T., Ichiyanagi, T., and Fukuda, K., Kitayama, J., Yamamoto, Y.,Kuramochi-Miyagawa, S., and Nakano, T., Yabuta, Y., Seki, Y., Saitou, M., and Sasaki, Hiroyuk. . (2011).
Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development.
Genome Research, 21, 2058-2066. [PubMed]
Abe, K., Naruse, C., Kato, T., Nishiuchi, T., Saitou, M., and Asano, M. (2011).
Loss of hererochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell-cycle progression in mice
Biology of Reproduction, 85, 1013-1024. [Biology of Reproduction]
Lee, J., Ogushi, S., Saitou, M., and Hirano, T. (2011).
Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes.
Molecular Biology of the Cell, 22, 3465-3477. [MBoC]
Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S., and Saitou, M. (2011).
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.
Cell, 146, 519-532. [Cell]
Hirota, T., Ohta, H., Shigeta, M., Niwa, H., and Saitou, M. (2011)
Drug-inducible gene recombination by the Dppa3-MER Cre MER transgene in the developmental cycle of the germ cell lineage in mice.
Biology of Reproduction, 85, 367-377 [Biology of Reproduction]
Inoue, A., Ogushi, S., Saitou, M., Suzuki, M.G., and Aoki, F. (2011).
Involvement of murine Nucleoplasmin 2 in the decondensation of sperm chromatin after fertilization.
Biology of Reproduction, 85, 70-77. [Biology of Reproduction]
Yabuta, Y., Ohta, H., Abe, T., Kurimoro, K., Chuma, S., and Saitou, M. (2011).
TDRD5 is required for retrotransposon silencing, chromatoid body assembly and spermiogenesis in mice.
The Journal of Cell Biology, 192, 781-795. [Kurenai]
Kurimoto, K., and Saitou, M. (2011).
A global single-cell cDNA amplification method for quantitative microarray analysis.
Methods in Molecular Biology, 687, 91-111. [Springer Link]


Yamagata, K., Ueda, J., Mizutani, E., Saitou, M., and Wakayama, T. (2010).
Survival and death of epiblast cells during embryonic stem cell derivation revealed by long-term live-cell imaging with an Oct4 reporter system.
Developmental Biology, 346, 90-101.  [PubMed]
Kurimoto, K., and Saitou, M.(2010)
Single-cell cDNA microarray profiling of complex biological processes of differentiation.
Current Opinion in Genetics and Development, 20, 470-477. [SciVerse]
Ogushi, S., and Saitou, M. (2010).
The nucleolus in the mouse oocyte is required for the early step of both female and male pronucleus organization.
Journal of Reproduction and Development, 56, 495-501. [Reproduction and Development]
Saitou, M., and Yamaji, M. (2010).
Germ cell specification in mice: Signalling, transcription regulation and epigenetic consequences.
Reproduction, 139, 931-942.  [Reproduction]
Miyauchi, Y., Ninomiya, K., Miyamoto, H., Sakamoto, A., Iwasaki, R., Hoshi, H., Miyamoto, K., Hao, W., Yoshida, S., Morioka, H., Chiba, K., Kato, S., Tokuhisa, T., Saitou, M., Toyama, Y., Suda, T., and Miyamoto, T. (2010).
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.
Journal of Experimental Medicine, 207, 751-762.  [JEM]
Yamaji, M., Tanaka, T., Shigeta, M., Chuma, S., Saga, Y., and Saitou, M. (2010).
Functional reconstruction of Nanos3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of Nanos3.
Reproduction, 139, 381-393.  [Reproduction]


Yamaguchi, S., Kurimoto, K., Yabuta, Y., Sasaki, H., Nakatsuji, N., Saitou, M., and Tada, T. (2009).
Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells.
Development, 136, 4011-4020. [Development]
Ohta, H., Ohinata, Y., Ikawa, M., Morioka, Y, Sakaide, Y., Saitou, M., Kanagawa, O., and Wakayama, T. (2009).
Male germline and embryonic stem cell lines from NOD mice: Efficient derivation of GS cells from a nonpermissive strain for ES cell derivation.
Biology of Reproduction, 81, 1147-1153. [Biology of Reproduction]
Saitou, M. (2009).
Germ cell specification in mice.
Current Opinion in Genetics and Development, 19, 386-395.  [SciVerse]
Ohinata, Y., Ohta, H., Shigeta, M., Yamanaka, K., Wakayama, T., and Saitou, M. (2009).
A signaling principle for the specification of the germ cell lineage in mice.
Cell, 137, 571-584. [Cell]
Saitou, M. (2009).
Specification of the germ cell lineage in mice.
Frontiers in Bioscience, 14, 1068-1087. [PubMed]


Seki, Y., and Saitou, M. (2008).
Epigenetic reprogramming in primoridial germ cell development.
Research Signpost, in Genetic and Epigenetic Control of Mammalian Germ Cell Development and Function 2008, 13-35.
Kurimoto, K., Yamaji, M., Seki, Y., and Saitou, M. (2008)
Specification of the germ cell lineage in mice: A process orchestrated by the PR-domain proteins, Blimp1 and Prdm14.
Cell Cycle, 7, 3514-3518. [CellCycle]
Kawaguchi, A., Ikawa, T., Kasukawa, T., Ueda, H. R., Kurimoto, K., Saitou, M., and Matsuzaki, F. (2008)
Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis.
Development, 135, 3113-3124. [Development]
Ohinata, Y., Sano, M., Shigeta, M., Yamanaka, K., and Saitou, M. (2008).
A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Blimp1-mVenus and stella-ECFP double transgenic reporter.
Reproduction, 136, 503-514. [PubMed]
Yamaji, M., Seki, Y., Kurimoto, K., Yabuta, Y., Yuasa, M., Shigeta, M., Yamanaka, K., Ohinata, Y., and Saitou, M. (2008).
Critical function of Prdm14 for the establishment of the germ cell lineage in mice.
Nature Genetics, 40, 1016-1022. [NatureGenetics]
Kurimoto, K., Yabuta, Y., Ohinata, Y., Shigeta, M., Yamanaka, K., and Saitou, M. (2008).
Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice.
Genes & Development, 22, 1617-1635. [CSH]
*Ogushi, S., Palmieri, C., Fulka, H., Saitou, M., Miyano, T., and Fulka Jr, J. (2008).
Maternal nucleolus is essential for early embryonic development in mammals.
Science, 319, 613-616. *Correspondence [Science]
Saitou, M., Yabuta, Y., and Kurimoto, K. (2008).
Single-cell cDNA high-density oligonucleotide microarray analysis: Detection of individual cell types and properties in complex biological processes.
Reprod. Biomed. Online, 16, 26-40.  [Reprod.Bilmed]


Seki, Y., Yamaji, M., Yabuta, Y., Sano, M., Shigeta, M., Matsui, Y., Saga, Y., Tachibana, M., Shinkai, Y., and Saitou, M. (2007).
Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice.
Development, 134, 2627-2638. [Development]
Kurimoto, K., Yabuta, Y., Ohinata, Y., and Saitou, M. (2007).
Global single-cell cDNA amplification to provide a template for representative high-density oligonucleotide microarray analysis.
Nature Protocols, 2, 739-752. [NatureProtocols]


Horsley, V., O’Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., and Fuchs, E. (2006).
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.
Cell, 126, 587-609.  [Cell]
Yabuta, Y., Kurimoto, K., Ohinata, Y., Seki, Y., and Saitou, M. (2006).
Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling.
Biology of Reproduction, 75, 705-716.  [Biology of Reproduction]
Ohinata, Y., Seki, Y., Payer, B., O’Carroll, D., Surani, M. A., and Saitou, M. (2006).
Germline recruitment in mice: A genetic program for epigenetic reprogramming.
Ernst Schering Research Foundation Workshop 60, 143-174.  [PubMed]
Kurimoto, K., Yabuta, Y., Ohinata, Y., Ono, Y., Uno, D. K., Yamada, R. G., Ueda, H. R., and Saitou, M. (2006).
An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis.
Nuc. Acids Res., 34, e42. [Nuc.AcidsRs]
Payer, B., Chuva de Sousa Lopes, S.M., Barton, S.C., Lee, C., Saitou, M., and Surani, M.A. (2006)
Generation of stella-GFP transgenic mice, a novel tool to study germ cell development.
Genesis, 44, 75-83.  [PubMed]


*Saitou, M., Payer, B., O’Carroll, D., Ohinata, Y., and *Surani, M.A. (2005).
Blimp1 and the emergence of the germ line during development in the mouse.
Cell Cycle, 4, 1736-1740. * Co-correspondence [CellCycle]
Western, P., Maldonado-Saldivia, J., van den Bergen, J., Hajkova, P., Saitou, M., Barton, S., and Surani, M.A. (2005).
Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2, and differences between human pluripotent cell lines.
Stem Cells, 23, 1436-1442  [PubMed]
Ohinata, Y., Payer, B., O’Carroll, D., Ancelin, K., Ono, Y., Sano, M., Barton, S. C., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., *Saitou, M., and *Surani, M.A. (2005).
Blimp1 is a critical determinant of the germ cell lineage in mice.
Nature, 436, 207-213.* Co-correspondence [PubMed]
Schulzke, J. D., Gitter, A. H., Mankertz, J., Spiegel, S., Seidler, U., Amasheh, S., Saitou, M., Tsukita, S., and Fromm, M. (2005).
Epithelial transport and barrier function in occludin-deficient mice.
Biochim. Biophys. Acta., 1669, 34-42. [PubMed]
Seki, Y., Hayashi, K., Itoh, K., Mizugaki, M., Saitou, M., and Matsui, Y. (2005).
Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice.
Dev. Biol. 278, 440-458. [PubMed]


Surani, M. A., Ancelin, K., Hajkova, P., Lange, U. C., Payer, B., Western, P., and Saitou, M. (2004).
Mechanism of mouse germ cell specification: A genetic program regulating epigenetic reprogramming.
Cold Spring Harbor Symposia on Quantitative Biology, Vol. LXIX., 69, 1-10 [CSH]


Payer, B., Saitou, M., Barton, S. C., Thresher, R., Dixon, J. P. C., Zahn, D., Colledge, W. H., Carlton, M. B. L., Nakano, T., and Surani, M.A. (2003).
Stella is a maternal effect gene required for normal early development in mice.
Curr. Biol. 13, 2110-2117. [Curr.Biol.]
Saitou, M., Payer, B., Lange, U. C., Erhardt, S., Barton, S. C., and Surani, M.A. (2003)
Specification of germ cell fate in mice.
Phil. Trans. Roy. Soc. 358, 1363-1370.  [Phil.Trans.Roy.Soc]
Lange, U. C., Saitou, M., Western, P., Barton, S. C., and Surani, M.A. (2003).
The Fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice.
BMC Dev. Biol. 3: Issue 1, 2003.  [BMC Dev]


Saitou, M., Barton, S. C., and Surani, M.A. (2002)
A molecular programme for the specification of germ cell fate in mice.
Nature, 418, 293-300.  [PubMed]