真核生物において、ゲノムDNAはタンパク質と結合し「クロマチン」と呼ばれる超分子複合体として折りたたまれて細胞核内に収納されています。クロマチンの多様な高次構造やその折りたたみ構造の違いが、遺伝子発現を制御することが、近年明らかになってきました。これは、DNA配列によらずに遺伝子機能を制御する “エピジェネティクス” の根幹と注目されています。


“Chromatin Atlas” Project

In eukaryotes, genomic DNA is associated with a variety of proteins, and is stored in the nucleus as a molecular complex termed “chromatin”. Over the last decade, the diverse higher-order structures adopted by chromatin, as well as its proper folding in the nucleus, have been revealed as crucial in the regulation of genome function.

We have defined the “Chromatin Atlas” as an ensemble of higher-order structures of chromatin units encoding its spatial information. Our goal is to comprehensively elucidate the structures and functions of the various chromatin units that build the “Chromatin atlas”, based on cryo-electron microscopy technology. Our “Chromatin Atlas” project aims to develop a new concept in how eukaryotic cells utilize genomic DNA as genetic material.

Chromatin Atlas Project