KANIE Osamu
Chemical Glyco-information Group Leader

Gifu Univ. Bachelor , Degree of Master
Nagoya City Univ. Doctoral degree
- 1990-1994
- University of Alberta, Canada, Postdoctoral fellow
- 1994-1996
- RIKEN, Special Researcher Program, Special Researcher
- 1996-1999
- RIKEN, Frontier Research Program, Glycotechnology Team, Deputy Leader
- 1999-2010
- Mitsubishi Kagaku Inst. of Life Sciences, Laboratory Head
- 2002-2006
- Key Technology Research Promotion Program of the New Energy and Industrial
Technology Development Organization (NEDO), Project Leader
- 2004-2007
- Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Adjunct Professor
- 2010-current
- JST, ERATO ITO Glycotrilogy Project, Chemical Glyco-information Group,
Group Leader
- 2011-current
- Tokai University, Institute of Glycoscience, Professor
- Alberta Heritage Foundation for Medical Research Award for "Synthetic
inhibitors of the metastasis-associated GlcNAcT-V"
- 3rd. The Japanese Society of Carbohydrate Research Award
- American Chemical Society
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
- The Japanese Society of Carbohydrate Research
- The Mass Spectrometry Society of Japan
and others
Publications with more than 30 citations |
ORTHOGONAL GLYCOSYLATION STRATEGY IN OLIGOSACCHARIDE SYNTHESIS. KANIE,
O; ITO, Y; OGAWA, T, Journal of the American Chemical Society, 116,
12073-12074, 1994: Times Cited: 161. |
STUDIES ON THE THIOGLYCOSIDES OF N-ACETYLNEURAMINIC ACID .5.
GLYCOSYLATION USING METHYLTHIOGLYCOSIDES OF N-ACETYLNEURAMINIC ACID AND
DIMETHYL(METHYLTHIO)SULFONIUM TRIFLATE. KANIE, O; KISO, M; HASEGAWA, A, Journal
of Carbohydrate Chemistry, 7, 501-506, 1988: Times Cited: 152. |
ACCEPTOR SUBSTRATE RECOGNITION BY N-ACETYLGLUCOSAMINYLTRANSFERASE-V -
CRITICAL ROLE OF THE 4''-HYDROXYL GROUP IN
BETA-D-GLCPNAC-(1->2)-ALPHA-D-MANP(1->6)-BETA-D-GLCP-OR. KANIE, O;
CRAWLEY, SC; PALCIC, MM; et al., Carbohydrate Research, 243, 139-164,
1993: Times Cited: 146. |
A lysoganglioside poly-L-glutamic acid conjugate as a picomolar
inhibitor of influenza hemagglutinin. KAMITAKAHARA, H; SUZUKI, T; NISHIGORI, N;
et al., Angewandte Chemie-International Edition, 37, 1524-1528, 1998:
Times Cited: 88. |
Orthogonal glycosylation strategy for rapid assembly of oligosaccharides
on a polymer support. ITO, Y; KANIE, O; OGAWA, T, Angewandte
Chemie-International Edition in English, 35, 2510-2512, 1996: Times Cited:
85. |
A strategy of ''random glycosylation'' for the production of
oligosaccharide libraries. KANIE, O; BARRESI, F; DING, YL; et al., Angewandte
Chemie-International Edition, 34, 2720-2722, 1995: Times Cited: 64. |
A versatile synthetic strategy for the preparation and discovery of new
iminocyclitols as inhibitors of glycosidases. TAKEBAYASHI, M; HIRANUMA, S;
KANIE, Y; et al., Journal of Organic Chemistry, 64, 5280-5291, 1999:
Times Cited: 45. |
Solid phase synthesis of polylactosamine oligosaccharide. SHIMIZU, H;
ITO, Y; KANIE, O; et al., Bioorganic & Medicinal Chemistry
Letters, 6, 2841-2846, 1996: Times Cited: 45. |
Quantitative monitoring of solid-phase synthesis using gated decoupling
C-13 NMR spectroscopy with a C-13-enriched protecting group and an internal
standard in the synthesis of sialyl Lewis(X) tetrasaccharide. KANEMITSU, T; KANIE,
O; WONG, CH, Angewandte Chemie-International Edition, 37, 3415-3418,
1998: Times Cited: 42. |
Towards oligosaccharide libraries: A study of the random galactosylation
of unprotected N-acetylglucosamine. DING, YL; LABBE, J; KANIE, O; et
al., Bioorganic & Medicinal Chemistry, 4, 683-692, 1996: Times
Cited: 42. |
A TRISACCHARIDE ACCEPTOR ANALOG FOR N-ACETYLGLUCOSAMINYLTRANSFERASE-V
WHICH BINDS TO THE ENZYME BUT STERICALLY PRECLUDES THE TRANSFER-REACTION. KHAN,
SH; CRAWLEY, SC; KANIE, O; et al., Journal of Biological Chemistry,
268, 2468-2473, 1993: Times Cited: 38. |
Orthogonal glycosylation strategy in synthesis of extended blood group B
determinant. KANIE, O; ITO, Y; OGAWA, T, Tetrahedron Letters, 37,
4551-4554, 1996: Times Cited: 37. |
Combinatorial library of five-membered iminocyclitol and the inhibitory
activities against glyco-enzymes. SAOTOME, C; WONG, CH; KANIE, O, Chemistry
& Biology, 8, 1061-1070, 2001: Times Cited: 36. |
Solid-phase synthesis of oligosaccharides and on-resin quantitative
monitoring using gated decoupling C-13 NMR. KANEMITSU, T; WONG, CH; KANIE, O,
Journal of the American Chemical Society, 124, 3591-3599, 2002: Times
Cited: 35. |
Synthesis and enzymatic evaluation of five-membered iminocyclitols and a
pseudodisaccharide. SAOTOME, C; KANIE, Y; KANIE, O; et al., Bioorganic
& Medicinal Chemistry, 8, 2249-2261, 2000: Times Cited: 34. |
For other publication list, click here.
- InterestsF
What is the origin of molecules used in forming life? Imagination explodes
when thinking back and forth in time. The evolution of our beings being
together with other beings sharing a same slice of time that is controlled
by the evolution of the universe itself intrigues us who might also share
the time with yet-to-see other intelligent beings. It was considered that
constituting fundamental molecules of life including nucleotides, amino
acids, and carbohydrates were "synthesized" on the earth in early
stage. However, no one knows why a series of polyhydroxylated amino acids
was not formed. Would new life form using atoms and elemental molecules
forming our bodies, which is spread to the space, as time goes and when
our solar system or the galaxy dies? What then would it be? Who knows the
"reason" of maintaining and delivering a "molecular logics"
as a genetic information among species along timeline. Although it is nonsense
trying to find any reason of the phenomenon, we also exist based on the
evidence and further developed to have nerve system and the brain that
is used for creating and delivering "artificial logics" such
as languages. The language has been enforced by the invention of methods
of storage (writing), multiplication (printing), and acceleration (computation)
and is always with us. Two of the different logics conceptually resemble
in the essence of the delivering information. Both logics do not seem to
care about the form or the shape. However, the rate and the volume of artificial
logics are continuing to increase. It is considered that such artificial
logics developed by one of the species, human, are governed by higher concept
of life that is the delivering information by means of molecular logics.
It might be natural to conclude that human is "required" to deliver
the artificial logics to not just some generations but some other intelligent
species emerging after human race extinct. Would it be possible for us
to deliver the logic itself to whom we know nothing about and to whom does
not exist yet? What if we find somewhere some foreign logic that has been
"sent" by others who lived billions of years ago? My thoughts
explode along the timeline and the space lately.

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