>> 2006f.y.Principle Investigators,Research Themes
>> 2008f.y.Principle Investigators,Research Themes
Manufacturing of Polymeric Nanoparticle Vaccines with Control Capability of Immune Responses

Mitsuru Akashi
Osaka University

URL : http://www.chem.eng.osaka-u.ac.jp/~akashi-lab/

This project is aimed at the development of biodegradable polymer-based nanoparticles with control capability of immune responses, and the establishment of manufacturing technology and pharmaceutical process for practical applications of polymeric nanoparticle vaccines. We design and prepare a safe and universal nanoparticle-based vaccine using nanoparticles capable of controlling intracellular kinetic of antigens and having adjuvant activity. This strategy will provide a novel immune therapy for infectious diseases, cancers, and autoimmune diseases.

Development of an automated synthesis apparatus and a large production for a highly functional molecule “Super catalytic antibody”

Uda, Taizo
Oita University

"Super catalytic antibody" is a nano-molecule and possesses sophisticated functions recognizing the targeted antigen with high specificity and can enzymatically cleave it. From the viewpoint of tailor-made therapy, in this study, we will develop essential and/or elemental technologies in order to complete the epochal tool (automated synthesis apparatus), with which a medical doctor can make the human "Super catalytic antibody" suitable for each patient. In addition, we will genetically make some human "Super catalytic antibodies", develop the large production method, and investigate their behavior in vivo. Through these studies, we will realize human "Super catalytic antibody" as the new medicine against infectious viruses and cancers as a front runner in the world.

Development of irreplaceable devices by creation of the second generation carbon nanotube

Hiromichi Kataura
Nanosystem Research Institute of Advanced Industrial Science and Technology
Group Leader
URL : http://staff.aist.go.jp/h-kataura/index.html

Carbon nanotubes (CNTs) are classified into two types, metals and semiconductors. The mixed production of them obstructed the practical use. In this project, we first develop a new technology to separate CNTs almost perfectly into semiconductors and metals. Further we insert other molecules into CNTs to control the electronic properties and finally create highly functional the second generation CNTs. By using them, we develop high-performance thin film transistors and non-linear optical devices exploiting the original potential of CNT. and organic LEDs.

Development of Innovative Synthesis Mehods of Nano-materials Using Ionic Liquid and Vacuum Techniques

Susumu Kuwabata
Osaka University
URL : http://www.chem.eng.osaka-u.ac.jp/~elechem/

Ionic liquid having negligible vapor pressure is not vaporized even in vacuum condition. Our experiments based on this unique feature led us to discovery of surprising phenomena; 1) Gold sputtering to ionic liquid results in synthesis of Au nanoparticles in the liquid; 2) Ionic liquid in a vacuum chamber can be observed by an electron microscope without any charging of the liquid. These must be the base technologies for developing novel nano-material synthesis and in situ measurements of chemical phenomena with several vacuum analytical instrument including electron microscopes. Realization of such the innovative ideas is the purpose of this research project.

Establishment of Process Navigation by Creation of Plasma Nano Science and Soft Material Processing

Masaru Hori
Nagoya University
URL : http://www.nuee.nagoya-u.ac.jp/labs/horilab/

In order to realize the future nano device manufacturing, we will make the paradigm shift from plasma process by a trial and error method to that on the basis of plasma science. The desktop combinatorial plasma analysis equipment with the monitoring technique for radical density, ion density and energy is developed and using the equipment, plasma nano science is created. Moreover, we will establish the guiding principle “process navigation” by the process data map based on plasma nano science. Herewith, innovative nano process manufacturing technology for organic soft materials is established.

3 Dimensional Molecular Imaging for Soft Materia

Jiro Matsuo
Kyoto University
Associate Professor
URL : http://sakura.nucleng.kyoto-u.ac.jp/index.html

A novel molecular imaging (secondary ion mass imaging) for soft materials used in bio-technology and molecular electronics is being developed with swift-heavy ions. In order to realize molecular depth profiling of soft materials, cluster ions will be utilized to remove soft materials without destroying molecular structure. Objective of this project is to offer a novel technique for nano-technology and bio-technology.
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