The research group has revealed that Menin, which is known as a tumor suppressor, inhibits CD4 T cell senescence. The T-cell specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by dysregulated expression of pro-inflammatory factors. The transcriptional repressor Bach2 was identified to be a downstream target of Menin that inhibits CD4 T cell senescence and abnormalities in pro-inflammatory factor expressions. The results will be useful for understanding the age-associated abnormalities in immune function.
Research Area: “Elucidation and control of the mechanisms underlying chronic inflammation”
Research Theme: “Control of the mechanisms underlying chronic inflammation through epigenetic modulation of T cell memory”
Makoto Kuwahara, Junpei Suzuki, Soichi Tofukuji, Takeshi Yamada, Makoto Kanoh, Akira Matsumoto, Saho Maruyama, Kohei Kometani, Tomohiro Kurosaki, Osamu Ohara, Toshinori Nakayama & Masakatsu Yamashita
“The MeninóBach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis”
Nature Communications, Published online 02 April 2014
Masakatsu Yamashita, Ph.D.
Professor, Department of Immunology, Ehime University Graduate School of Medicine
Koji Matsuo, Takafumi Kawaguchi, and Toshiyuki Shingo
Life Innovation Group, Department of Innovation Research, JST