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Masayuki Inoue |
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Chemical Synthesis and Rational Design
of Voltage-sensitive Ion Channel |
(Professor, The University of Tokyo, Graduate School of Pharmaceutical Sciences) |
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Voltage-sensitive channels are the highly functional
nano-devises that control our sensation, emotions,
thought and movement in nerve and muscle. Despite
the importance, the large-molecular weight (M.W. >100,000)
and the chemical instability have impeded the detailed
study of its dynamic function. PTA-A is the largest
non-ribosomal peptide (M.W. 5000) that forms a
stable voltage-sensitive trans-membrane pore. Our
goals of the project are to construct the general
synthetic route to PTA-A, to understand its channel
function, and to control the dynamic behavior.
These studies will be the basis of new design principle
of the biomimetic nano-devises. |
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