[Haruhiko Koseki] Analysis and application for regulation of cell function on linked mechanisms of enhancer dynamics and transcription regulation by epigenetic control


Research Director

Haruhiko Koseki

Haruhiko Koseki

RIKEN
Group Director
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Outline

The deep understanding on the transcription regulation in variety of organs and tissues is required to establish and optimize the protocols for cell/organ induction in vitro. It is known that the genomic element called enhancer has important roles in transcriptional regulation within each tissue/organ. However, the mechanisms how an enhancer activates some repressed gene promoter remain elusive. In our proposed study, we will clarify the dual step mechanisms how an enhancer interacts to repressed promoter and how an enhancer liberates the promoter from repression. We further inspect and pursue whether such interaction can be proper indication for sound differentiation and induction of tissue/organ in vitro.

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