Outline
The purpose of this research is to elucidate the mechanisms through which inflammation becomes chronic, and the creation of basic technologies for the early detection, control, resolution, and reparation of chronic inflammation.
More specifically, this involves research aimed at
1) identifying factors that induce and maintain the chronicity of inflammation by determining failure mechanisms of inflammation control;
2) clarifying the mechanisms through which specific diseases (including cancer, degenerative neurological disorders, and arteriosclerotic diseases) develop as a result of chronic inflammation, and to create basic technologies to control them; and
3) creating basic technologies that allow the early detection and quantitative assessment of chronic inflammation. This not only involves established basic or clinical research, but also emphasizes on research that sufficiently sublimes evidence-based findings for understanding high-dimensional inflammation control mechanisms, and leads to the development of new preemptive basic medical technologies.
Strategic Sector
Creation of basic medical technologies for the prevention, diagnosis and treatment of cancer, arteriosclerotic diseases, and autoimmune disorders by the elucidation of the mechanisms underlying chronic inflammation
Research Projects
Research Director | Affiliation | Research Project |
---|---|---|
Issei Komuro | Professor, Osaka University | Pathophysiological role of chronic inflammation in aging-associated diseases |
Toshinori Nakayama | Professor, Chiba University | Regulation of chronic inflammation and the development of new strategies for treating airway inflammatory diseases |
Osamu Nureki | Professor, The University of Tokyo | Structural basis for the pathogenic disease mechanisms caused by chronic inflammation |
Mitsuru Matsumoto | Professor, Tokushima University | Control of chronic inflammation through elucidation of organ-specific autoimmune disease mechanisms |
Kouji Yasutomo | Professor, Tokushima University | Identification of critical genes involved in the pathogenesis of human chronic inflammatory diseases |
Masayuki Yamamoto | Professor, Tohoku University | Protective mechanisms against environmental stresses leading to therapeutic strategies for chronic inflammation |
- Research Area Website
- http://www.inflammation.jst.go.jp/?lang=en