Research Project Outline
It is generally believed that even if a particular neural system is injured, compensation of its function may be possible to some extent, if residual systems can afford to take over the lost function. However the mechanism of such functional compensation is not yet clear. In this study, we will investigate the compensatory mechanisms of (1) dexterous finger movements following the lesion of corticospinal tract at the cervical spinal cord level, and (2) visuo-motor functions following the lesion of primary visual cortex by using non-human primates as experimental models. We will aim at understanding these compensatory mechanisms from regulation of gene expression to system levels. The results will lead us to develop new and more efficient methods in neuro-rehabilitation.
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