Metabolism-based Regulation of Organelle Homeostasis and Cell Function

Research Project Outline

Peroxisome functions in numerous essential metabolic pathways such as the synthesis of ether-lipid plasmalogens and is involved in human neurological disorders and the production of many useful proteins in yeast systems. We delineate the mechanisms underlying the homeostasis, biogenesis and degradation, of peroxisome as a model organelle and metabolic disorders caused by its homeostasis dysregulation, by investigating the dynamism of molecular network regulated by the metabolism. We also establish the basic techniques applicable to developing the diagnostic as well as therapeutic agents for the neurological disease and producing recombinant proteins and food supply.

Related Links

• Laboratory Website: http://www.biology.kyushu-u.ac.jp/%7Etaisha/ (Japanese)