Research Project Outline
Upon infection, immune cells are activated and produce cytokines through recognition of these pathogens by pathogen-associated molecular pat-tern recognition molecules such as TLR or C-type lectins, resulting in the eladication of these pathogens. However, excess activation of this system may also cause allergy and autoimmunity. In this project, we will analyze the functional roles of cytokines including IL-17A/IL-17F and C-type lectins including Dectin-1/2 and Dcir in the development of dis-eases such as rheumatoid arthritis, allery, and infectious diseases, and try to develop novel therapeutics against these diseases.