Research Project Outline
Ultimate single molecular detection techniques can measure minute conformational changes of functional protein molecules with atomic size accuracy under the time resolution of microsecond in the place where biological functions appear in the cell. This program will achieve both high-speed Diffracted Xray Tracking (DXT) and laboratory size Diffracted electron Tracking (DET), which are individual single molecular detection system using high-energy probes. Additionally, we will propose and develop scanning x-ray radiation pressure microscope (XPM). The above-mentioned three methodologies will observe a minute structural difference in molecular recognition under the immunity system and the bio-membrane system which are very important phenomena in the life science.
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