Research Project Outline
The aim of this study is the structural analysis of biomolecular complexes in the cell by electron tomography, using molecular labels which can be observed by electron microscopy. The biomolecular tomography requires the development of both the new method of genetical labeling with metal-binding proteins and the integration of the hardware and software for electron tomography applying to biological specimens. It leads to the general understanding of physiological functions of biomolecular complexes through the analysis of their threedimensional structure and arrangement in the cell.
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