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KANIE Osamu


Chemical Glyco-information Group Leader


Gifu Univ. Bachelor , Degree of Master
Nagoya City Univ. Doctoral degree


Brief summary of career
1990-1994
University of Alberta, Canada, Postdoctoral fellow
1994-1996
RIKEN, Special Researcher Program, Special Researcher
1996-1999
RIKEN, Frontier Research Program, Glycotechnology Team, Deputy Leader
1999-2010
Mitsubishi Kagaku Inst. of Life Sciences, Laboratory Head
2002-2006
Key Technology Research Promotion Program of the New Energy and Industrial Technology Development Organization (NEDO), Project Leader
2004-2007
Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Adjunct Professor
2010-current
JST, ERATO ITO Glycotrilogy Project, Chemical Glyco-information Group, Group Leader
2011-current
Tokai University, Institute of Glycoscience, Professor


Award
  • Alberta Heritage Foundation for Medical Research Award for "Synthetic inhibitors of the metastasis-associated GlcNAcT-V"
  • 3rd. The Japanese Society of Carbohydrate Research Award


Scientific Society
  • American Chemical Society
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • The Japanese Society of Carbohydrate Research
  • The Mass Spectrometry Society of Japan

and others

 Publications with more than 30 citations  
 ORTHOGONAL GLYCOSYLATION STRATEGY IN OLIGOSACCHARIDE SYNTHESIS. KANIE, O; ITO, Y; OGAWA, T, Journal of the American Chemical Society, 116, 12073-12074, 1994: Times Cited: 161.
 STUDIES ON THE THIOGLYCOSIDES OF N-ACETYLNEURAMINIC ACID .5. GLYCOSYLATION USING METHYLTHIOGLYCOSIDES OF N-ACETYLNEURAMINIC ACID AND DIMETHYL(METHYLTHIO)SULFONIUM TRIFLATE. KANIE, O; KISO, M; HASEGAWA, A, Journal of Carbohydrate Chemistry, 7, 501-506, 1988: Times Cited: 152.
 ACCEPTOR SUBSTRATE RECOGNITION BY N-ACETYLGLUCOSAMINYLTRANSFERASE-V - CRITICAL ROLE OF THE 4''-HYDROXYL GROUP IN BETA-D-GLCPNAC-(1->2)-ALPHA-D-MANP(1->6)-BETA-D-GLCP-OR. KANIE, O; CRAWLEY, SC; PALCIC, MM; et al., Carbohydrate Research, 243, 139-164, 1993: Times Cited: 146.
 A lysoganglioside poly-L-glutamic acid conjugate as a picomolar inhibitor of influenza hemagglutinin. KAMITAKAHARA, H; SUZUKI, T; NISHIGORI, N; et al., Angewandte Chemie-International Edition, 37, 1524-1528, 1998: Times Cited: 88.
 Orthogonal glycosylation strategy for rapid assembly of oligosaccharides on a polymer support. ITO, Y; KANIE, O; OGAWA, T, Angewandte Chemie-International Edition in English, 35, 2510-2512, 1996: Times Cited: 85.
 A strategy of ''random glycosylation'' for the production of oligosaccharide libraries. KANIE, O; BARRESI, F; DING, YL; et al., Angewandte Chemie-International Edition, 34, 2720-2722, 1995: Times Cited: 64.
 A versatile synthetic strategy for the preparation and discovery of new iminocyclitols as inhibitors of glycosidases. TAKEBAYASHI, M; HIRANUMA, S; KANIE, Y; et al., Journal of Organic Chemistry, 64, 5280-5291, 1999: Times Cited: 45.
 Solid phase synthesis of polylactosamine oligosaccharide. SHIMIZU, H; ITO, Y; KANIE, O; et al., Bioorganic & Medicinal Chemistry Letters, 6, 2841-2846, 1996: Times Cited: 45.
 Quantitative monitoring of solid-phase synthesis using gated decoupling C-13 NMR spectroscopy with a C-13-enriched protecting group and an internal standard in the synthesis of sialyl Lewis(X) tetrasaccharide. KANEMITSU, T; KANIE, O; WONG, CH, Angewandte Chemie-International Edition, 37, 3415-3418, 1998: Times Cited: 42.
 Towards oligosaccharide libraries: A study of the random galactosylation of unprotected N-acetylglucosamine. DING, YL; LABBE, J; KANIE, O; et al., Bioorganic & Medicinal Chemistry, 4, 683-692, 1996: Times Cited: 42.
 A TRISACCHARIDE ACCEPTOR ANALOG FOR N-ACETYLGLUCOSAMINYLTRANSFERASE-V WHICH BINDS TO THE ENZYME BUT STERICALLY PRECLUDES THE TRANSFER-REACTION. KHAN, SH; CRAWLEY, SC; KANIE, O; et al., Journal of Biological Chemistry, 268, 2468-2473, 1993: Times Cited: 38.
 Orthogonal glycosylation strategy in synthesis of extended blood group B determinant. KANIE, O; ITO, Y; OGAWA, T, Tetrahedron Letters, 37, 4551-4554, 1996: Times Cited: 37.
 Combinatorial library of five-membered iminocyclitol and the inhibitory activities against glyco-enzymes. SAOTOME, C; WONG, CH; KANIE, O, Chemistry & Biology, 8, 1061-1070, 2001: Times Cited: 36.
 Solid-phase synthesis of oligosaccharides and on-resin quantitative monitoring using gated decoupling C-13 NMR. KANEMITSU, T; WONG, CH; KANIE, O, Journal of the American Chemical Society, 124, 3591-3599, 2002: Times Cited: 35.
 Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide. SAOTOME, C; KANIE, Y; KANIE, O; et al., Bioorganic & Medicinal Chemistry, 8, 2249-2261, 2000: Times Cited: 34.


For other publication list, click here.



  • InterestsF
    What is the origin of molecules used in forming life? Imagination explodes when thinking back and forth in time. The evolution of our beings being together with other beings sharing a same slice of time that is controlled by the evolution of the universe itself intrigues us who might also share the time with yet-to-see other intelligent beings. It was considered that constituting fundamental molecules of life including nucleotides, amino acids, and carbohydrates were "synthesized" on the earth in early stage. However, no one knows why a series of polyhydroxylated amino acids was not formed. Would new life form using atoms and elemental molecules forming our bodies, which is spread to the space, as time goes and when our solar system or the galaxy dies? What then would it be? Who knows the "reason" of maintaining and delivering a "molecular logics" as a genetic information among species along timeline. Although it is nonsense trying to find any reason of the phenomenon, we also exist based on the evidence and further developed to have nerve system and the brain that is used for creating and delivering "artificial logics" such as languages. The language has been enforced by the invention of methods of storage (writing), multiplication (printing), and acceleration (computation) and is always with us. Two of the different logics conceptually resemble in the essence of the delivering information. Both logics do not seem to care about the form or the shape. However, the rate and the volume of artificial logics are continuing to increase. It is considered that such artificial logics developed by one of the species, human, are governed by higher concept of life that is the delivering information by means of molecular logics. It might be natural to conclude that human is "required" to deliver the artificial logics to not just some generations but some other intelligent species emerging after human race extinct. Would it be possible for us to deliver the logic itself to whom we know nothing about and to whom does not exist yet? What if we find somewhere some foreign logic that has been "sent" by others who lived billions of years ago? My thoughts explode along the timeline and the space lately.


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