Decoding and Controlling Brain
            Information   PRESTO   Japan Science and Technology
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Phase 1

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Phase 3

AMANO, Kaoru HARUNO, Masahiko HOSOYA, Haruo KAMIKOUCHI, Azusa KAWANO, Takeshi
MIYATA, Mariko MORIGUCHI, Yusuke TAMADA, Atsushi TOKUDA, Takashi
TSUCHIYA, Naotsugu YAMADA, Makiko YAO, Ikuko


AMANO, Kaoru
PI, Center for Information and Neural Networks, National Institute of Information and Communications Technology
Title:
Decoding temporal information in perception using MEG
Summary:
I propose a model to predict the timing of visual or sound perception using neural responses non-invasively recorded with magnetoencephalography (MEG). By quantitatively analyzing the change in the model parameters with the manipulation of stimuli, I study the neural representation of temporal information in perception. While establishing the method to study the neural representation using decoding technique, I pursue the possibility of application such as the breaking system based on brain signals.

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HARUNO, Masahiko
PI, Center for Information and Neural Networks, National Institute of Information and Communications Technology
Title:
Evolutional reiforcement learning model to explain the diversity seen in social dynamics
Summary:
This study constructs evolutional reiforcement learning model to explain the diversity seen in social dynamics. Taking advantage of its ability to predict individual differences in division of resources, we aim to design an fMRI neurofeedback based information system which can promote cooperation in social interaction by changing offers reflecting on each person's characteristics and state of brain activity.

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HOSOYA, Haruo
Researcher, PRESTO, JST
(Department of Dynamic Brain Imaging (DBI), Brain Information Communication Research Laboratory Group, ATR)
Title:
Modeling visual cortex by a Bayesian network and decoding cognitive signals from higher visual areas
Summary:
Visual cortex performs complex visual cognitions with its hierarchically structured system. The present research aims at constructing a theoretically solid model of visual cortex based on a Bayesian network, and thereby reproducing and predicting properties of higher visual cortex in a systematic way. Moreover, as an application to brain-machine interfaces, a method will be investigated for reading out cognitive information on visual objects from activities of higher visual areas recorded by fMRI.

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KAMIKOUCHI, Azusa
Professor, Graduate School of Science, Nagoya University
Title:
Analysis on the neural basis that process acoustic information in the fruitfly brain.
Summary:
In this project, the fruit fly Drosophila melanogaster will be used as the model system to the study of the neural coding and information processing in the auditory system. Here, we will (1)construct the fine anatomical map of higher-order auditory circuit in the fly brain, (2)elucidate the relationship between sound stimuli and the activity patterns in the neural circuit, (3)analyze the behavioral changes evoked by activity manipulation of each neural circuit, and by doing so, (4)open a new field in the "Flybrain-machine interface".

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KAWANO, Takeshi
Associate Professor, Departments of Engineering, Toyohashi University of Technology
Title:
Electrical, chemical, optical micro/nano-scale neuroprobe arrays
Summary:
The goal of this project is to develop integrated electrical, chemical, optical micro/nano scale silicon probe/silicon-dioxide tube arrays with microelectronics, to contribute the future of neuroscience: low invasive high spatial resolution probe arrays for brain cortices; nanoscale probe arrays; microtube array-based local drug delivery systems and optical neurostimulators.

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MIYATA, Mariko
Chair Professor, Department of Physiology, Tokyo Women's Medical Univ.
Title:
Morphofunctional remodeling of neronal circuits in the central nervous system after peripheral nerve injury
Summary:
Neuronal circuits in the central nervous system are remodeled as a consequence of peripheral nerve injury. To know how the circuits and synapses are remodeled is one of the critical issues for understanding the compensatory potential of the brain after the injury. This in turn can assist in developing treatment strategies for the functional recovery. In this study, I will challenge to visualize the somatosensory information on sensory afferent fibers onto the thalamus using genetically manipulated mice, and to reveal the fundamental rules that govern the morphofunctional remodeling of neuronal circuits in the central nervous system after peripheral nerve injury.

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MORIGUCHI, Yusuke
Associate Professor, Department of School Education, Graduate School of Education, Joetsu University of Education
Title:
Decoding children's brain to understand their unique cognitive world
Summary:
Research on developmental psychology suggests that children perceive some "imaginary" agents that adults cannot perceive. However, there is no scientific evidence to support children's reports. This project aims to establish technique to decode children's brain, and using the technique, to examine whether children really perceive the agents. I will apply the technique to infer infants and children's psychological and physiological states.

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TAMADA, Atsushi
Associate Professor, Center for Transdisciplinary Research, Niigata University
Title:
Elucidation of structural and functional left-right brain asymmetry
Summary:
The brain is mostly bilaterally symmetric at the level of gross morphology, but it is significantly asymmetric in terms of functions. In human, the left cortical hemisphere processes language, whereas the right hemisphere is specialized for spatial cognition. What is the left-right structural asymmetry at the level of neural circuits? How does the structural asymmetry generate the functional asymmetry? In this project, I challenge these issues with a focus on the rotational neuronal motility driven by molecular motors. The findings will promote our understanding of complex mental functions such as language, cognition, memory and thinking.

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TOKUDA, Takashi
Associate Professor, Graduate School of Materials Science, Nara Institute of Science and Technology
Title:
Development of opto-electronic neural interface and neuro-LSI hybrid BMI using LSI microchip technology
Summary:
Based on bio-implantable LSI technology, I develop multifunctional nural interaface microchip which can stimulate and observe the neuralcell using both light and electricity. I will demonstrate feasibility of the proposed LSI-based neural interface and BMI technology. I also pursue a new breakthrough to propose and demonstrate hybrid logic systems that consisting of biological and LSI systems.

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TSUCHIYA, Naotsugu
Associate Professor, School of Psychology and Psychiatry, Monash University, Australia
Title:
Revealing functional connectivity between distant brain areas that support higher cognitive functions through exploration of simultaneous multi-electrode recordings
Summary:
Higher cognitive functions, such as consciousness and attention, are supported by transient changes in the strength of 'functional connectivity' between neuronal populations. To reveal the mechanisms of the functional connectivity, neuronal activities have to be recorded simultaneously from many electrodes at high spatiotemporal resolution. However, the multi-electrode data are highly voluminous and complex, very difficult to visualize the results for intuitive understanding. Overcoming such a difficulty, I aim to reveal the complex flow of the information that supports consciousness and attention.

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YAMADA, Makiko
Subleader, Clinical Neuroimaging Team, Molecular Neuroimaging Program, National Institute of Radiological Sciences
Title:
Neural mechanism of derealization
Summary:
Derealization is a subjective sense of unreality that is caused by an alteration in the perception or experience of the external world. In this project, I aim to uncover the neural mechanisms that are related to the altered perception of the outside world, using psychophysics and brain imaging methods.

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YAO, Ikuko
Associate Professor, Medical Photonics Research Center, Hamamatsu University School of Medicine
Title:
Visualization of Neurotransmitter using imaging mass spectrometory
Summary:
The purpose of this study is to reveal the neural activity dependent-neurotransmitter dynamics, with a concept of “clarifying the spatiotemporal regulation of brain information”. To visualize neurotransmitters, I will use the technique of “imaging mass spectrometry” and link the findings to integrated solution. These results of this study will influence not only the basic research but also the treatment of many neurologic disorders with abnormal neurotransmitter release, and novel rehabilitation approaches.

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