They found a new hydroxynitrile lyase (HNL) with the highest specific activity toward benzaldehyde and wide temperature and pH stabilities from a millipede. Since the HNL is highly enantioselective in the synthesis of various cyanohydrins, it is expected as the next generation biocatalyst for production of R-specific cyanohydrins.
ERATO Asano Active Enzyme Molecule Project
Mohammad Dadashipour, Yuko Ishida, Kazunori Yamamoto, and Yasuhisa Asano. “Discovery and molecular and biocatalytic properties of hydroxynitrile lyase from an invasive millipede, Chamberlinius hualienensis”. Proceedings of the National Academy of Sciences of the United States of America, vol. 112 no. 34, 2015, doi: 10.1073/pnas.1508311112.
Yasuhisa Asano, Ph.D.
Professor, Toyama Prefectural University
Department of Research Project, JST
K’s Goban-cho 7, Goban-cho, Chiyoda-ku, Tokyo 102-0076 Japan
Tel: +81-3-3512-3528 Fax: +81-3-3222-2068