Molecular chaperones are known to suppress misfolding of cellular proteins in each individual cell. Here we reveal that molecular chaperones are unexpectedly secreted from cells and are transmitted to surrounding cells via exosomes, which leads to suppression of aggregate formation of misfolded proteins related to neurodegenerative diseases in surrounding cells.
Research Area “Creation of a Novel Technology towards Diagnosis and Treatment Based on Understanding of Molecular Pathogenesis of Psychiatric and Neurological Disorders”
Research Theme “Development of Comprehensive Therapies for Polyglutamine Diseases”
Takeuchi T, Suzuki M, Fujikake N, Popiel HA, Kikuchi H, Futaki S, Wada K, and Nagai Y. “Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level”. Proceedings of the National Academy of Sciences of the United States of America, Published Online April 27, 2015. doi: 10.1073/pnas.1412651112.
Yoshitaka Nagai, MD, PhD.
Section Chief, Department of Degenerative Neurological Diseases, National Center of Neurology and Psychiatry
Life Innovation Group Department of Innovation Research, JST