The research group has revealed that EZH2, which is known as a repressor of gene expression, acts on the immune system and controls excessive immune responses. They made gene maps of the place where EZH2 bound and clarified a mechanism underlying expression of immune-related genes mediated by EZH2.
Research Area: “Creation of basic medical technologies to clarify and control the mechanisms underlying chronic inflammation”
Research Theme: “Regulation of chronic inflammation and the development of new strategies for treating airway inflammatory diseases”
Damon J. Tumes, Atsushi Onodera, Akane Suzuki, Kenta Shinoda, Yusuke Endo, Chiaki Iwamura, Hiroyuki Hosokawa, Haruhiko Koseki, Koji Tokoyoda, Yutaka Suzuki, Shinichiro Motohashi, Toshinori Nakayama.
“The Polycomb Protein Ezh2 Regulates Differentiation and Plasticity of CD4+ T Helper Type 1 and Type 2 Cells” Immunity, 2013,
Professor, Graduate School of Medicine, Chiba University
1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, JAPAN
Life Innovation Group
Department of Innovation Research
Japan Science and Technology Agency