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JST Press Release

Oct. 31, 2013
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666
URL http://www.jst.go.jp/EN/index.html

Discovery of novel molecules that regulate pathology of spinocerebellar ataxia.

By using systems biology, we newly identified two DNA damage repair genes, RpA1 and Chk1, to be involved in the pathology of a neurodegenerative disease, spinocerebellar ataxia type 1 (SCA1). We also revealed that modulation of the two genes remarkably extended lifespan of SCA1 model flies.

Researcher Information

Research Area: “Creation of a Novel Technology towards Diagnosis and Treatment Based on Understanding of Molecular Pathogenesis of Psychiatric and Neurological Disorders”
Research Theme: “Development of Comprehensive Therapies for Polyglutamine Diseases”

Journal Information

Barclay S, Tamura T, Ito H, Fujita K, Tagawa K, Shimamura T, Katsuta A, Shiwaku H, Sone M, Imoto S, Miyano S, Okazawa H
“Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1”
Human Molecular Genetics
doi: 10.1093/hmg/ddt524


[About Research]
Hitoshi Okazawa
Professor, Department of Neuropathology, Division of Pathophysiology, Medical Research Institute,
Tokyo Medical and Dental University

[About Program]
Takafumi Kawaguchi
Life Innovation Group, Department of Innovation Research,
Japan Science and Technology Agency


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/