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JST Press Release

5th June 2013
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666
URL http://www.jst.go.jp/EN/index.html

Three proteins capable to induce limb regeneration responses in axolotls

Inductive stuffs which can induce limb regeneration responses have been sought for a long time. We found such stuffs in axolotl. Gdf5, Fgf2, and Fgf8 application into wounded axolotl skin resulted in a limb. Thus, these three proteins can be used as a regenerative medicine for urodele amphibians. This finding can be expected to make a new approach for limb regeneration in higher vertebrates.

Researcher Information

JST PRESTO Research Area “Understanding Life by iPS Cells Technology”
Research Theme “Stepwise regulation of the cellular dedifferentiation”

Journal Information

Aki Makanae, Ayako Hirata, Yasuko Honjo, KazumasaMitogawa and Akira Satoh
“Nerve independent limb induction in axolotls”
Published online in “Developmental Biology”
doi: 10.1016/j.ydbio.2013.05.010


[About Research]
Akira SATOH, Ph.D.
Associate Professor, Okayama University, R.C.I.S.

[About Program]
Takafumi Kawaguchi, Fumiharu Kimura,
Life Science Group, Department of Innovation Research
Japan Science and Technology Agency (JST)


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