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JST Press Release

7th February 2013
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666
URL http://www.jst.go.jp/EN/index.html

Deciphering the molecular mechanism underlying the degradation of damaged mitochondria

Mitophagy is the degradation system for damaged mitochondria, and believed to be relevant to Parkinson’s disease. We have now found that certain anti-apoptotic proteins translocate from the mitochondria to the endoplasmic reticulum during mitophagy, thereby escaping degradation. Our results may elucidate the pathoetiology of Parkinson’s disease.

Researcher Information

JST CREST Research Area “The Dynamic Mechanism of and Fundamental Technology for Biological System”, Research Theme : “Establishment of the analytical basis toward comprehensive understanding of the ubiquitin system”

Journal Information

Shotaro Saita, Michiko Shirane & Keiichi I. Nakayama
“Selective escape of proteins from the mitochondria during mitophagy”
doi: 10.1038/ncomms2400


[About Research]
Professor, Medical Institute of Bioregulation, Kyushu University
Keiichi Nakayama
HP: http://www.bioreg.kyushu-u.ac.jp/saibou/index_en.html

[About Program]
Life Innovation Group
Department of Innovation Research
Japan Science and Technology Agency
Shigeru Ishimasa
HP: http://www.jst.go.jp/kisoken/crest/en/index.html


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/