Mitophagy is the degradation system for damaged mitochondria, and believed to be relevant to Parkinson’s disease. We have now found that certain anti-apoptotic proteins translocate from the mitochondria to the endoplasmic reticulum during mitophagy, thereby escaping degradation. Our results may elucidate the pathoetiology of Parkinson’s disease.
Researcher Information
JST CREST Research Area “The Dynamic Mechanism of and Fundamental Technology for Biological System”, Research Theme : “Establishment of the analytical basis toward comprehensive understanding of the ubiquitin system”
Journal Information
Shotaro Saita, Michiko Shirane & Keiichi I. Nakayama
“Selective escape of proteins from the mitochondria during mitophagy”
NATURE COMMUNICATIONS, 2013
doi: 10.1038/ncomms2400
Contact
[About Research]
Professor, Medical Institute of Bioregulation, Kyushu University
Keiichi Nakayama
E-mail:
HP: http://www.bioreg.kyushu-u.ac.jp/saibou/index_en.html
[About Program]
Life Innovation Group
Department of Innovation Research
Japan Science and Technology Agency
Shigeru Ishimasa
E-mail:
HP: http://www.jst.go.jp/kisoken/crest/en/index.html