The paper reports detailed structural analysis of polymeric micelles used for anticancer drugs or gene delivery. We used a rather new method in soft material research, so-called anomalous small-angle x-ray scattering (ASAXS). The analysis was done at SPring-8, one of the brightest synchrotron X-ray sources in the world. ASAXS revealed that the hydrophobic drugs were infiltrating into the water-soluble domain of the micelles. This finding provides useful insight to understand the drug delivery mechanism and to design more efficient DDS carriers.
JST CREST Research Area “Development of the foundation for nano-interface technology”,
Research Theme : “Manipulation of nano interface of drug-delivery system and its application to vaccine for bird flu”
Published in “Journal of the American Chemical Society”
The Journal of the American Chemical Society is a weekly peer-reviewed scientific journal that was established in 1879 by the American Chemical Society. It publishes original research papers in all fields of chemistry. According to the Journal Citation Reports, it is the most cited journal in this field and has an impact factor of 9.907 in 2011.
Link to the article:
“Hydrophobic Molecules Infiltrating into the PEG Domain of the Core/Shell Interface of a Polymeric Micelle: Evidence Obtained with Anomalous Small-Angle X-ray Scattering”
Kazuo Sakurai Ph.D.,
Professor, Faculty of Environmental Engineering,
The University of Kitakyushu
Green Innovation Group, Department of Innovation Research,
Japan Science and Technology Agency,