We uncovered the mechanism of spontaneous restoration of the injured neuronal network in multiple sclerosis brain and spinal cord, and succeeded in improvement of the symptom. These findings establish the concept that blood vessels promote regeneration of the neurons, and are expected to development of molecular targeting therapeutic drugs.
JST CREST Research Area “Elucidation of the Principles of Formation and Function of the Brain Neural Network and Creation of Control Technologies”¸
Research Theme : “Elucidation of mechanisms of neural network reorganization and functional recovery after brain injury”
Published in the scientific journal “Nature Medicine”
Rieko Muramatsu¸ Chisato Takahashi¸ Shuzo Miyake¸ Harutoshi Fujimura¸ Hideki Mochizuki¸ and Toshihide Yamashita
“Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin”
Nature Medicine¸ doi:10.1038/nm.2943
Toshihide Yamashita¸ MD¸ Ph.D.
Professor¸ Graduate School of Medicine¸ Osaka University
Life Innovation Group¸ Department of Innovation Research¸ Japan Science and Technology Agency