Summary of the project

By leveraging our proprietary epigenomic data from juvenile suicide cases and innovative AMPA receptor-based brain technologies, we aim to: 1）develop biomarkers that visualize risks and recovery from abuse, depression, and suicide in youth; 2) uncover biological mechanisms of stress and resilience from early adversity; 3) design evidence-based systems to support emotional regulation; 4) identify ethical, legal, and social barriers to real-world implementation. These efforts seek to make invisible risks visible, reveal therapeutic targets, and advance a society free from child abuse, depression, and suicide.

Milestone by the end of the project (2032)

Development and validation of “the Youth Mental Stress and Resilience Test (YM-STAR)”:

To establish non-invasive and feasible biological markers capable of predicting child abuse and suicide risk, and to evaluate their applicability and effectiveness in clinical, welfare, and educational support settings.

Milestone by the end of the project (2027)

Epigenomic age and related data were analyzed in 400 individuals, with additional assessment of information impact and ELSI awareness.

R&D theme progress reports

• [1] Brain AMPA receptor data and epigenome data for abuse and suicidality
• [2] Comprehensive epigenome data and single-cell gene expression data for child abuse and suicidality
• Progress Report (591KB)

Performers

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• Summary of the project (316KB)